LIMITED ELEVATIONS IN ANTITUBERCULOSIS DRUG-INDUCED SERUM ALANINE AMINOTRANSFERASE (ALT) LEVELS IN A COHORT OF NIGERIANS ON TREATMENT FOR PULMONARY TUBERCULOSIS AND HIV INFECTION IN YENAGOA.

Peter Ogie Ikuabe, Ikenna Desmond Ebuenyi, Tubonye Clement Harry

Available online Jul 19, 2018.

[ Original ] Volume 24, Issue 2, 2015, Pages 103-107


Abstract

BACKGROUND
This study,undertaken in a major tertiary hospital in the Niger Delta region of Nigeria was designed to examine the
incidence of elevation in serum alanine aminotransference (ALT) in our patients who were on treatment for
HIV/AIDS with some of them on antituberculosis drugs.
METHOD
Between January and December 2014,all admission records which include HIV status,Acid fast bacilli Status,Chest
radiograph,CD4 cell count, degree of hepatotoxicity during antituberculosis drugs treatment according to WHO
definition using clinical findings and ALT levels at baseline (ALT1) and at 4 weeks into treatment with
antituberculosis drugs (ALT2) of all the patients on HAART with some on antituberculosis drugs were retrieved
and retrospectively analyzed.
RESULTS
Of the total of 707 patients on HAART,80 were on both HAART and anti-tuberculosis treatment.There was a
2 statistically significant correlation between ALT1 levels in the PTB negative and PTB positive cohort at baseline X =
10.725,d.f 4,P = 0.030.
After 4 weeks of antituberculosis treatment and HAART ALT2 level in expectedly, generally showed downward
2 trend with no statistically significant correlation between PTB status and ALT2 (X = 0.789,d.f2.P = 0.674)
CONCLUSION
Anti-tuberculosis drug induced elevation in alanine amino transference is unexpectedly low in our patients on
treatment for pulmonary tuberculosis and HIV infection.This is a key finding that requires further studies.


Keywords

Tuberculosis, HIV, HAART, Alanine aminotransferase,