PREVALENCE OF SICKLE CELL GENE AMONG APPARENTLY HEALTHY UNDER-TWO SOUTH-EAST NIGERIAN CHILDREN:

Okocha Chide, Onubogu Chinyere Ukamaka, Aneke John, Onah Christian, Ajuba Ifeoma, Ibeh Nancy, Egbuonu Ifeoma

Available online Jul 18, 2018.

[ Original ] Volume 25, Issue 2, 2016, Pages 176-181


Abstract

This cross-sectional descriptive study examined the role of parental premarital counselling and socio-demographic
characteristics on the prevalence of sickle cell gene among 82 apparently healthy under-two children.
METHODS:
Subjects were recruited from under-two children attending child welfare clinic at Nnamdi Azikiwe University
Teaching Hospital, Nnewi, South-East, Nigeria.
RESULTS:
More than half of their mothers were aware of their hemoglobin phenotype (64.6%) and that of their husbands
(53.6%). In about half of the families (52.4%), the parents had a premarital counselling intervention against sickle cell
disease (SCD). Among the 44 families where parents were aware of their phenotype before marriage, only one
couple (2.3%) was at risk of having an offspring with SCD. None of the subjects had SCD and the prevalence of
sickle cell trait (SCT) among them was 22%. Premarital counselling intervention in families seemed to increase the
prevalence of SCT when compared to those not counselled but this was not statistically significant (p = 0.30). The
lower prevalence of SCT among children of more educated women suggests that educational status may affect the
distribution of the sickle cell gene in the population.
CONCLUSION/RECOMMENDATION:
Premarital counselling and screening may be effective in reducing the prevalence of SCD but the higher prevalence
of SCT among the population where this intervention occurred portends an ominous sign for the future.
Integration of malaria eradication and competent genetic counselling, with avoidance of discrimination against
people with SCT or SCD, into screening programmes are essential for reducing the burden and impact of SCD.


Keywords

Sickle cell gene, sickle cell disease, prevalence, premarital screening, counselling.,

April-June 2016

Volume 25 | Issue 2

Page Nos. 176-181

Online since Jul 12, 2018

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