THE PREDICTIVE VALUE OF SERUM URIC ACID FOR THE OCCURRENCE, SEVERITY AND OUTCOMES OF PRE-ECLAMPSIA AMONG PARTURIENTS AT NNEWI , NIGERIA

1Osakwe Chukwudi Richmond, Ikpeze Okechukwu C, 2 3 4 Ezebialu Ifeanyi Uzoma, Osakwe Joy Oluchi, Mbadugha Norah Nwadiogo

Available online Jul 19, 2018.

[ Original ] Volume 24, Issue 3, 2015, Pages 192-200


Abstract

OBJECTIVE: To determine the predictive value of serum uric acid for preeclampsia, its severity and
pregnancy outcome.
METHODS:This is a cohort study that was performed on normal pregnant women attending antenatal
clinic at Nnamdi Azikiwe University Teaching Hospital Nnewi Nigeria.Serum uric acid was determined in
200 women attending antenatal clinic between the gestational ages of 14 and 26 weeks.The women were
followed up at 2 weekly intervals until 36 weeks and weekly thereafter until delivery.Women who
developed pre-eclampsia or eclampsia were identified. Pregnancy outcomes were determined as well as fetal
and placental weights. The data was analysed with SPSS version 16.0. The chi square was used for test of
significance.The positive and negative predictive values were determined.
RESULTS:A total of 200 normal pregnant women were recruited for the study.Nine of them were lost to follow
up.Subsequently,10.5% of the women developed preeclampsia.The positive and negative predictive values of serum
uric acid for preeclampsia were 78.9% and 97.1%,respectively.
CONCLUSION:Serum uric acid was found to be a useful predictor of the occurrence of preeclampsia and its
severity.


Keywords

serum uric acid, preeclampsia, predictive value, occurrence, severity,

July - September 2015

Volume 24 | Issue 3

Page Nos. 192-200

Online since Jul 12, 2018

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